They face off against an Everton outfit lacking form and confidence, sitting 17th in the table heading into the midweek fixtures and with just one win in their last five league games.
However, speaking before the game, Klopp stressed that the Reds’ city rivals cannot be expected to roll over.
“Are we in a better moment in the league table? Yes,” he said.
“But the stats from my point of view help Everton rather than us; they want to strike back, they want to show they can do it differently, they can sort a lot of problems in one game.
“Everybody thinks there is no doubt about this team, how much they are connected to the club, and when you are then this is a game that whichever situation you are in, you want to win.”
Liverpool: Adrian; Alexander-Arnold, Lovren, Van Dijk, Robertson; Wijnaldum, Lallana, Milner; Shaqiri, Origi, Mane
Substitutes: Kelleher, Gomez, Keita, Henderson, Oxlade-Chamberlain, Salah, Firmino
Everton: Pickford; Holgate, Mina, Keane; Sidibe, Davies, Sigurdsson, Digne; Iwobi, Richarlison, Calvert-Lewin
Substitutes: Lossl, Baines, Schneiderlin, Bernard, Walcott, Tosun, Kean